is to   
Apr 11 2015
(Original) Photographs by Getty Images
Curt Schilling
Well, the rest of your life up to
the point when you are
diagnosed with cancer. I get what
you’re thinking. You’re 16 — you’
re invincible, just like all your
buddies. If you were to jump
ahead 33 years, you couldn’t
write a better dream than the one
your life is going to be.
Dear 16-year-old Curt,
Tomorrow at lunch, a kid is going to dare
you to take a dip of Copenhagen. If you say
yes, like I did, you’ll be addicted for the
rest of your life.
Nicotine and the Developing Human:
A Neglected Element in the Electronic Cigarette Debate
Published Online: March 16, 2015           - or -

With Thanks to: Karen Zielaski, Project Manager, Consultant,, 480.678.3869
No Smoking Including E-cigarettes and All Other Electronic Smoking Devices
Tobacco 21 (T21) in Arizona
​Tobacco 21 or T21 is a fairly new tobacco control effort in Arizona however it is gathering momentum.  On 06/02/2016 Yavapai Anti-Tobacco Coalition of
Youth (YATCY) encouraged the Cottonwood City Council to pass an ordinance to raise the age to purchase tobacco products and e-cigarettes from 18 to 21.  
Cottonwood is Arizona's 1st T21 Community!
​Effective 08/11/17 we are very proud to announce that the Cochise County Youth Health Coalition (DCrew) has encouraged the Douglas City Council to also
pass an ordinance to raise the age to purchase tobacco products and e-cigarettes from 18 to 21.  
Douglas is Arizona's 2nd T21 Community!

​Other T21 efforts in Arizona are on-going.  There is currently an effort in Tucson and Tempe.  Watch this space for more details.
​The reasons for Tobacco 21 are numerous.  

Here's the national Tobacco 21 website ( with more information including a state-by-state analysis of Tobacco 21 status/achievements:
Vanishing Y Chromosomes
A new study reveals an association between smoking and rates of Y chromosome loss in blood
cells, which may explain elevated cancer risk among male smokers.
By Molly Sharlach |
December 4, 2014
Decades of epidemiological data demonstrate that men have higher overall cancer rates than women. This difference in risk is more than four-fold for
some types of cancer, but the reasons for the disparity remain mostly mysterious.

In an investigation of blood samples from more than 1,000 men, scientists at Uppsala University in Sweden and their colleagues found that those with
higher rates of chromosome Y loss tended to die younger and were more susceptible to a variety of cancers. Now, some of the same researchers have
shown that smoking behavior is strongly linked to the loss of the Y chromosome—a relatively common occurrence. The results, reported today
(December 4) in Science, suggest a mechanism for the increased risk of many cancers observed in male smokers compared to female smokers.

This work “provides an interesting hypothesis for a biological mechanism that could contribute to the sex ratio in cancer,” said cancer epidemiologist
Ellen Chang of the Stanford School of Medicine who was not involved in the study. “It certainly doesn’t provide a definitive answer,” she added. “It’s
more of a hypothesis.”

To explore potential causes for the loss of the Y chromosome, Uppsala’s Jan Dumanski, Lars Forsberg, and their colleagues examined the blood samples
and medical records of 6,000 Swedish men from three independent cohorts. They used single-nucleotide polymorphism (SNP) array analysis to quantify
the loss of the Y chromosome (LOY) in blood cells, and then tested for associations between LOY rates and factors such as age, education level,
exercise habits, smoking, and cholesterol levels.

“We analyzed many, many different potential confounders, but smoking was sticking out,” said Forsberg. “In all three cohorts, we see an independent
effect: that smokers have more loss of Y in their blood compared to nonsmokers.”
In two of the groups, the team was able to compare LOY levels in men
who were current smokers to LOY levels in those who had quit. Strikingly, they found that former smokers had LOY rates similar to those of men who had
never smoked. Further, data on smoking frequency suggested that occasional smokers experienced less LOY than heavier smokers, added Forsberg.

The researchers hypothesize that the loss of the Y chromosome may give cells a “proliferative advantage” due to the elimination of important
regulators—an idea consistent with recent evidence that the Y chromosome contains tumor suppressor genes. While LOY in blood cells may reflect this
process in many cell types, it is also possible that specific cancer-fighting abilities are compromised in immune cells that lack the Y chromosome.

In a small experiment, the researchers sorted blood cells from three 91-year-old cancer-free members of the Uppsala Longitudinal Study of Adult Men,
which was initiated in 1970. This analysis showed low levels of LOY in CD4+ T cells, which participate in cancer immunosurveillance, but higher LOY rates
in other cell types. Forsberg said his team is working to obtain samples from a larger group of men to follow up on this finding.

While the underlying molecular links between smoking, LOY, and cancer remain unclear, this work contributes to “a rising tide of respect for and interest
in the Y chromosome and its role in human biology and health and disease,” said David Page, an expert on sex chromosome biology and the director of
the Whitehead Institute for Biomedical Research in Cambridge, Massachusetts. “The publication of this paper in a high-profile journal is symptomatic of
that.” Until recently, Page added, scientists believed the Y chromosome contributed only to sex determination and male fertility, but “it’s now plausible
that loss of the Y chromosome could have consequences in every nook and cranny of the body.”

J.P. Dumanski et al., “Smoking is associated with mosaic loss of chromosome Y,” Science, doi:10.1126/science.1262092, 2014.
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"The Arizona Community Foundation and
its Affiliates are a statewide philanthropy
and partnership of donors, volunteers,
staff, nonprofit organizations and the
community working together to empower
and align philanthropic interests with
community needs and build a legacy of
Arizonans Concerned About Smoking, Inc., a 501(c)(3) Corporation, would like to expressour appreciation for
partial funding provided by
Arizona Community Foundation.
With your generous support, we are able to blaze new trails into areas where others fear to tread.
We can continue our life-saving health educational efforts thanks to you.
"Partial funding provided by the Arizona Community Foundation"
Smoke-Free Arizona has been the law since May, 2007;
however un-lawful smoking sometimes continues to occur
well within 20 feet of all Arizona Business entrances.

How Arizona Businesses Can Comply with the Law:  
Smoke-Free Arizona Business Compliance

How to Report a Violation (iPhone and Android Apps are
Smoke-Free Arizona Report Violations

The public is encouraged to report businesses that are not in
compliance with the Smoke-Free Arizona Act to the Arizona
Department of Health Services. Complainants may choose to
remain anonymous. County health departments are in charge of
investigating complaints about violations of the Smoke-Free
Arizona Act.

To learn more or if You have questions call us at (480) 733-5864.
Is this what You sometimes see at Arizona Business entrances?  If so, please
report it.  You can report it easily and anonymously or by submitting an
on-line complant.  See how to report a violation on the left.  To submit a
complaint You can also call (877) 429-6676.  Thank You for being a SFA
Advocate in Your Community!
11th Annual ACAS Health Leadership Award Ceremony on 02.23.19
Watch this space for more information about our 11th Annual Health Leadership Award Ceremony on February 23, 2019

When: February 23, 2019, 10 AM to 12 Noon.    Where: Tempe Pyle Adult Center, 655 E Southern Ave. Tempe, AZ 85282
(Southwest Corner of Rural and Southern, just north of U.S. 60)                                 
2019 (Tobacco Control) Health Leadership Inductees:

Nonsmokers, Incorporated - First successful workplace ballot initiative against the tobacco industry in the U.S.
Graham County Students Taking a Road to Success (STARS) - Smoke Free Parks, No E-Cigarettes Allowed - Thatcher, AZ
City Council of Prescott, Arizona - Smoke Free Parks, No E-Cigarettes Allowed - Prescott, AZ
Town Council of Fountain Hills, Arizona - Smoke-Free Parks, No E-Cigarettes Allowed - Fountain Hills, AZ
Arizona Students Aiming for Prevention (ASAP) - Flagstaff adds E-Cigarettes to their Tobacco Control policy (as of 01.10.19)
Coconino Anti-Tobacco Students (CATS) - Flagstaff adds E-Cigarettes to their Tobacco Control policy (as of 01.10.19)

For pictures from 8th (2016), 9th (2017) and 10th (2018) Annual Health Leadership Award Ceremonies click
The Tobacco Control Legal Consortium provides an outstanding Model Ordinance for Tobacco 21 for Your Community.  Here's the link to their model policy:

Tobacco 21 Model Ordinance

The Tobacco Control Legal Consortium also provides a Toolkit:

Tobacco21:  Tips and Tools

Please contact us at (480) 733-5864 for more information or to learn how to help make Tobacco 21 a reality in Your community here in Arizona.